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If rhabdomyolysis is suspected, the drug should be stopped immediately, and appropriate medical management should be instituted as well as a work-up of predisposing risk factors. For patients found to have statin-induced rhabdomyolysis, consideration should be given to switching to an alternate LDL-lowering drug such as ezetimibe, a recently approved inhibitor of intestinal cholesterol absorption.

Copyright 2021, CMA Joule Inc. ISSN 1488-2329 (e) 0820-3946 (p)All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries. To receive any of these resources in an accessible format, please contact us at CMA Joule Inc.

Mississauga (ON): Astra Zeneca Canada Inc. OpenUrlCrossRefThompson PD, Clarkson, P, Karas RH. OpenUrlCrossRefPubMedStaffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis. OpenUrlCrossRefPubMed PreviousNext Back to top In this issue Vol. Show more Synopsis Collections Topics Drugs: cardiovascular system Drugs: adverse reactions googletag. ISSN 1488-2329 (e) 0820-3946 (p) All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.

Board-Certified Urologist Trent B. Crestor (rosuvastatin calcium) is a popular statin used along with diet and exercise to lower bad cholesterol by blocking liver enzymes. Doctors also prescribe the drug to slow plaque buildup in arteries and to prevent heart disease, heart attacks, strokes and other cardiovascular diseases.

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Crestor is part of a family of cholesterol-lowering drugs known as statins that includes Lipitor, Zocor and Lescol. The medication is designed to work with proper diet and exercise to lower bad cholesterol and slow the buildup of fatty deposits in the walls or blood vessels, which may prevent heart attacks and strokes. The active ingredient is rosuvastatin calcium. Rosuvastatin has been shown to reduce the risk of heart attack and other heart-related adverse events over 1.

But there have been no long-term studies examining the effects of taking it or any other statins for as long as 20 or 30 years, which is the length of time many people will take the medicine. Crestor is part of a class of drugs called statins. In 2010, the FDA approved the drug for additional uses including prevention of heart attacks, strokes and certain heart-related procedures among fairly healthy people with elevated C-reactive protein (CRP) levels, which is a marker of inflammation.

AstraZeneca manufactures the drug, which is approved for use in more than 115 countries. Generic versions have been available since 2016. Crestor comes in tablets that vary in color, shape and size depending on the dosage. Doses range from 5 mg to 40 mg taken once a day at any time, with or without food. The change told doctors to consider starting Asian patients at just 5 mg once daily.

Such elevated levels can increase the risk of muscle damage. The label warns that people with a known hypersensitivity to ingredients in the drug should not take it.

Rosuvastatin is also not recommended for people with active liver disease, women who are pregnant or who may become pregnant, or nursing mothers. The most common side effects of Crestor may include muscle aches, weakness, abdominal pain, nausea and headache. The drug has also been associated with a risk of kidney and liver damage, and a possible increased risk of developing diabetes. Let your doctor know if you experience unexplained muscle pain or weakness, or if you continue to have muscle problems even after your doctor has told you to stop taking Crestor.

You should also alert your doctor if your urine is dark, your skin or eyes are yellowing, your stomach hurts or your appetite has changed.